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Page 1
KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions.
Barro-Soria R, Ramentol R, Liin SI, Perez ME, Kass RS, Larsson HP. Barro-Soria R, et al. Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7367-E7376. doi: 10.1073/pnas.1710335114. Epub 2017 Aug 14. Proc Natl Acad Sci U S A. 2017. PMID: 28808020 Free PMC article.
How KCNE1 and KCNE3 subunits modify KCNQ1 channel gating so differently is largely unknown. Here, we use voltage clamp fluorometry to determine how KCNE1 and KCNE3 affect the voltage sensor and the gate of KCNQ1. ...
How KCNE1 and KCNE3 subunits modify KCNQ1 channel gating so differently is largely unknown. Here, we use voltage clamp fluorometry to …
Functional significance of channels and transporters expressed in the inner ear and kidney.
Lang F, Vallon V, Knipper M, Wangemann P. Lang F, et al. Am J Physiol Cell Physiol. 2007 Oct;293(4):C1187-208. doi: 10.1152/ajpcell.00024.2007. Epub 2007 Aug 1. Am J Physiol Cell Physiol. 2007. PMID: 17670895 Free article. Review.
All these channels and transporters are also expressed in the kidney and support renal tubular transport or signaling. The hearing loss may thus be paralleled by various renal phenotypes including a subtle decrease of proximal Na(+)-coupled transport (KCNE1/KCNQ1), …
All these channels and transporters are also expressed in the kidney and support renal tubular transport or signaling. The hearing lo …
BACE1 and presenilin/gamma-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.
Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY. Sachse CC, et al. FASEB J. 2013 Jun;27(6):2458-67. doi: 10.1096/fj.12-214056. Epub 2013 Mar 15. FASEB J. 2013. PMID: 23504710 Free PMC article.
Elevated alpha-secretase or BACE1 activities increased C-terminal fragment (CTF) levels of KCNE1 and 2 in human embryonic kidney (HEK293T) and rat neuroblastoma (B104) cells. ...Furthermore, the elevated BACE1 activity increased KCNE1 processing and shifted …
Elevated alpha-secretase or BACE1 activities increased C-terminal fragment (CTF) levels of KCNE1 and 2 in human embryonic kidney …
KCNE1 does not shift TMEM16A from a Ca(2+) dependent to a voltage dependent Cl(-) channel and is not expressed in renal proximal tubule.
Talbi K, Ousingsawat J, Centeio R, Schreiber R, Kunzelmann K. Talbi K, et al. Pflugers Arch. 2023 Aug;475(8):995-1007. doi: 10.1007/s00424-023-02829-5. Epub 2023 Jul 13. Pflugers Arch. 2023. PMID: 37442855 Free PMC article.
Here we demonstrate that KCNE1 is not expressed in mouse RPT. TMEM16A expressed in RPT is activated by angiotensin II and ATP in a KCNE1-independent manner. Coexpression of KCNE1 does not change TMEM16A to a voltage gated Cl(-) channel and Ca(2+)-dependent re …
Here we demonstrate that KCNE1 is not expressed in mouse RPT. TMEM16A expressed in RPT is activated by angiotensin II and ATP in a …
Genetic disorders of transporters/channels in the inner ear and their relation to the kidney.
Peters TA, Monnens LA, Cremers CW, Curfs JH. Peters TA, et al. Pediatr Nephrol. 2004 Nov;19(11):1194-201. doi: 10.1007/s00467-004-1626-6. Epub 2004 Sep 9. Pediatr Nephrol. 2004. PMID: 15365806 Review.
Genetic disorders in transporters/channels for chloride (ClC-K), bicarbonate (Cl(-)/HCO(3)(-) exchanger), protons (H(+)-ATPase), sodium (ENaC, NKKC1, NBC3, NHE3), potassium (KCNQ1/KCNE1, Kcc4), and water (AQP4) in the inner ear and their relation to the kidney are d …
Genetic disorders in transporters/channels for chloride (ClC-K), bicarbonate (Cl(-)/HCO(3)(-) exchanger), protons (H(+)-ATPase), sodium (ENa …
Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport.
Lang F, Vallon V. Lang F, et al. Clin Exp Nephrol. 2012 Feb;16(1):73-80. doi: 10.1007/s10157-011-0488-z. Epub 2011 Nov 1. Clin Exp Nephrol. 2012. PMID: 22038256 Review.
SGK1-regulated K(+) channels include renal outer medullary K+ channel, Kv1.3, Kv1.5, KCNE1/KCNQ1, KCNQ4 and, via regulation of calcium (Ca(2+)) entry, Ca(2+)-sensitive K(+) channels. ...
SGK1-regulated K(+) channels include renal outer medullary K+ channel, Kv1.3, Kv1.5, KCNE1/KCNQ1, KCNQ4 and, via regulation of calciu …
Meniere's Disease: Molecular Analysis of Aquaporins 2, 3 and Potassium Channel KCNE1 Genes in Brazilian Patients.
Lopes Kde C, Sartorato EL, da Silva-Costa SM, de Macedo Adamov NS, Ganança FF. Lopes Kde C, et al. Otol Neurotol. 2016 Sep;37(8):1117-21. doi: 10.1097/MAO.0000000000001136. Otol Neurotol. 2016. PMID: 27509294
CONCLUSIONS: The genetic variant rs426496 in AQP2; rs591810 in AQP3 and rs1805127, rs1805128, and rs17173510, in KCNE1 were found in patients with Meniere's disease. The polymorphism rs426496, in AQP2, is associated with tinnitus at the onset of Meniere's disease and alter …
CONCLUSIONS: The genetic variant rs426496 in AQP2; rs591810 in AQP3 and rs1805127, rs1805128, and rs17173510, in KCNE1 were found in …
(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.
Lang F, Böhmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. Lang F, et al. Physiol Rev. 2006 Oct;86(4):1151-78. doi: 10.1152/physrev.00050.2005. Physiol Rev. 2006. PMID: 17015487 Free article. Review.
Similar to its isoforms SGK2 and SGK3, SGK1 is activated by insulin and growth factors via phosphatidylinositol 3-kinase and the 3-phosphoinositide-dependent kinase PDK1. SGKs activate ion channels (e.g., ENaC, TRPV5, ROMK, Kv1.3, KCNE1/KCNQ1, GluR1, GluR6), carriers (e.g. …
Similar to its isoforms SGK2 and SGK3, SGK1 is activated by insulin and growth factors via phosphatidylinositol 3-kinase and the 3-phosphoin …
Properties and regulation of the minK potassium channel protein.
Kaczmarek LK, Blumenthal EM. Kaczmarek LK, et al. Physiol Rev. 1997 Jul;77(3):627-41. doi: 10.1152/physrev.1997.77.3.627. Physiol Rev. 1997. PMID: 9234960 Review.
The minK gene encodes a protein of 130 amino acids that has a single transmembrane segment and is expressed in many tissues including heart, uterus, and kidney. When Xenopus oocytes are injected with minK mRNA, a very slowly activating voltage-dependent potassium current i …
The minK gene encodes a protein of 130 amino acids that has a single transmembrane segment and is expressed in many tissues including heart, …
Upregulation of KCNQ1/KCNE1 K+ channels by Klotho.
Almilaji A, Pakladok T, Muñoz C, Elvira B, Sopjani M, Lang F. Almilaji A, et al. Channels (Austin). 2014;8(3):222-9. doi: 10.4161/chan.27662. Channels (Austin). 2014. PMID: 24457979 Free PMC article.
KCNQ1/KCNE1 expressing oocytes were treated with human recombinant Klotho protein (30 ng/mL) for 24 h. ...KCNQ1/KCNE1 channel activity and KCNQ1/KCNE1 protein abundance were upregulated by coexpression of Klotho. ...
KCNQ1/KCNE1 expressing oocytes were treated with human recombinant Klotho protein (30 ng/mL) for 24 h. ...KCNQ1/KCNE1 channel …
62 results